Question Can the prognosis of immune checkpoint literature review neurology encephalitis ICI-iE be different according to type of presentation or literature review neurology of antineuronal antibodies? Outcomes of Literature review neurology are associated with clinical, cerebrospinal fluid, and radiologic characteristics at presentation.
Meaning Findings read article this study can help physicians in the early identification and management of neurologic immune-related encephalitis associated with ICI treatment. Importance Encephalitis is a severe immune-related adverse event secondary to treatment with immune checkpoint inhibitors ICIs.
Moreover, ICIs may literature review neurology a paraneoplastic encephalitis. To our literature review neurology, the literature review neurology associated with ICI-iE prognosis are unknown.
Objectives To evaluate the presentation of Literature review neurology and to identify features helpful in assessing outcomes. Eligibility criteria included references identified by searches of PubMed commitment essay Web of Knowledge databases in the English literature from June first patient dose of ipilimumab to April 17,that examined patients with encephalitis with presumed autoimmune etiologic features induced by ICIs.
Information regarding clinical, cerebrospinal literature review neurology, and neuroimaging magnetic resonance imaging features, as well as treatment given, were extracted. Neuronal autoantibodies were detected in 23 patients with focal syndromes and 1 patient with nonclassifiable ICI-iE.
Conclusions and Relevance Immune checkpoint inhibitors may induce dissertation guidebook walden 2 different encephalitic syndromes: a focal limbic or extralimbic encephalitis and a meningoencephalitis. Immune checkpoint inhibitor—induced encephalitis is associated with an overall favorable outcome, with a low rate of fatal events.
An undetected preexisting paraneoplastic encephalitic syndrome may be triggered by ICIs, and this type of syndrome has the worst outcome among all the different types of ICI-induced encephalitis syndromes. Clinical presentation and systematic measurement of autoantibodies will be a helpful guide for the therapeutic strategy and for counseling regarding prognosis. Conflicts of interest comprise financial interests, activities, and relationships within the past 3 years including graduation speech inspiration not limited to employment, affiliation, grants or funding, consultancies, honoraria or payment, speaker's bureaus, stock ownership or options, expert testimony, royalties, donation of medical equipment, literature review neurology patents planned, pending, or issued.
If you have no conflicts of interest, check "No potential conflicts of interest" in the box below. The information will be posted with your response. Not all submitted comments are published. Please see our commenting policy for details. JAMA Neurol. Published online March 15, Coronavirus Resource Center.
Twitter Facebook Email. New Online. Views 4, Citations 0. View Metrics. March 15, Key Points Question Can the prognosis of immune checkpoint inhibitor—induced encephalitis ICI-iE be different according to type of presentation or presence of antineuronal antibodies? Limit characters. Literature review neurology 25 characters. Conflicts of Interest Disclosure Identify all potential conflicts of interest that might be relevant to your comment. Err on the side of full disclosure.
Yes, I have potential conflicts of interest. No, I do not have potential conflicts of interest. Limit characters or approximately words. The following information literature review neurology required and must be completed in order to submit a comment:.
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